Semax shows up on almost every "nootropic peptide" list sold in India, but most of those pages give it one paragraph before moving on. This guide is a standalone deep-dive: what Semax actually is, where its ACTH(4-10) origin comes from, what the research literature actually studies it for, its price across every size, and how to source a properly documented batch. For a side-by-side comparison against Selank, see our Semax & Selank nootropic peptides guide; this article goes deeper on Semax alone.
- Semax is a synthetic heptapeptide corresponding to the ACTH(4-10) fragment, modified for stability.
- It's studied mainly in cognition, neuroprotection and BDNF-pathway research models.
- At OMNIPOTENT it's HPLC ≥99% pure with a batch COA, from ₹5,899, with a 10 mg size and BAC-water bundles.
What is Semax?
Semax is a synthetic heptapeptide built from the 4–10 fragment of adrenocorticotropic hormone (ACTH), with a C-terminal tripeptide addition that stabilises it against rapid enzymatic breakdown. Unlike the original ACTH molecule, Semax has no hormonal (corticotropic) activity of its own — the fragment was isolated specifically because that region of ACTH was found to carry independent biological activity once separated from the rest of the hormone.
The ACTH(4-10) origin, explained
ACTH is best known for its role in the adrenal stress-response axis, but researchers found that a short internal fragment — residues 4 through 10 — retained activity in central-nervous-system models even after the fragment was clipped away from the hormone's endocrine function. That discovery, made in Russian research institutions, is the basis for Semax and the reason it's classified as a neuropeptide rather than a hormone analogue, despite its ACTH lineage.
Where Semax appears in research
Semax research clusters around three connected themes: cognitive-performance models, neuroprotection (particularly in ischemia and injury models), and the BDNF (brain-derived neurotrophic factor) pathway, which recurs across a large share of the published literature on this compound. BDNF's role as a key neurotrophic factor is one of the more frequently cited mechanistic threads connecting Semax research to broader neuroscience literature, and it's a useful search term if you're trying to find primary sources rather than secondary summaries.
Semax vs Selank — two different families
Semax and Selank are sold together constantly, but they aren't structurally related. Semax derives from ACTH and is studied mainly in cognition and neuroprotection models; Selank derives from tuftsin and is studied mainly in anxiety and immune-modulation models. The only real thing they share is a Russian research origin and a short, stable heptapeptide structure — which is exactly why they're bundled commercially even though their research focus diverges. We cover the comparison directly in our Semax & Selank guide, and we've published a standalone Selank deep-dive as well.
Semax price in India
At OMNIPOTENT, Semax starts at ₹5,899 for a 5 mg vial, HPLC ≥99% pure with a COA. Larger sizes and a bacteriostatic-water bundle are available on the product page:
| 5 mg | ₹5,899 |
| 5 mg + 10 ml BAC water | ₹6,899 |
| 10 mg | ₹10,499 |
| 10 mg + 10 ml BAC water | ₹11,499 |
Bundling a 10 ml bottle of bacteriostatic water with either size is usually the more practical choice for labs that don't already keep a stock of it on hand for reconstitution, and it's priced as a small add-on rather than a separate full-price purchase.
Reconstitution, storage & handling
Semax ships as a lyophilised powder in a sealed vial. Some published protocols reference intranasal-format handling for this compound class, but regardless of the model, storage principles are the same: reconstitute with bacteriostatic water, refrigerate immediately, and protect from light. Our step-by-step reconstitution guide covers the full process, and our coaches are available free of charge after every order.
Sourcing & verifying purity
Because Semax is a short, delicate peptide chain, batch-to-batch consistency matters — always insist on a batch-specific Certificate of Analysis rather than a generic purity claim, and cross-check the HPLC figure against the exact vial you receive. Our guide to verifying peptide purity and COAs explains what to look for, and our buyer's guide to research peptides in India covers sourcing fundamentals more broadly.
Semax and related ACTH-derived compounds
Semax is sometimes discussed alongside other ACTH(4-10)-derived variants, including N-Acetyl Semax, each carrying a different terminal modification aimed at altering stability or clearance. OMNIPOTENT supplies standard Semax — the form most consistently referenced across the published literature — which keeps results comparable with existing studies rather than introducing an unverified analogue into a research design.
As with any short heptapeptide, sequence fidelity during synthesis directly affects how a batch performs in a research model; a single truncated or substituted residue can materially change receptor behaviour. HPLC purity testing alone confirms the absence of major impurities, so mass-spec identity confirmation — available on request with every OMNIPOTENT batch — is the additional step that verifies the sequence itself is correct.
Researchers sourcing Semax for the first time often ask how shelf-life compares once reconstituted. Lyophilised peptide powder is generally stable for extended periods when kept cold and protected from light, while reconstituted solution has a shorter practical window and should be refrigerated and used within the timeframe your protocol specifies. Our reconstitution guide and coaches can walk through the specifics for your setup.
Semax in the broader peptide research landscape
ACTH-derived compounds like Semax sit within a wider category of neuropeptides studied for central-nervous-system effects, alongside structurally unrelated but thematically adjacent compounds such as DSIP, which is studied in a different area of neuropeptide research. Researchers assembling a broader cognition- or neuroprotection-focused research panel often reference Semax as one data point within that larger picture.
Semax
ACTH(4-10) research heptapeptide, HPLC ≥99% with a batch COA. Free coach guidance, fast pan-India delivery.
Frequently asked questions
What is Semax studied for in research?
Semax is a synthetic heptapeptide corresponding to the ACTH(4-10) fragment, studied in cognition, neuroprotection and BDNF-pathway research models. It is supplied strictly as a reference compound for in-vitro laboratory research.
How is Semax different from Selank?
Semax is an ACTH(4-10) analogue studied mainly in cognition and neuroprotection models, while Selank is a tuftsin analogue studied mainly in anxiety and immune-modulation models. They come from different peptide families despite often being grouped together as "nootropic peptides."
How much does Semax cost in India?
Semax starts at ₹5,899 at OMNIPOTENT, HPLC ≥99% pure with a batch COA. A 10 mg size and a BAC-water bundle are also available.
What is the origin of Semax?
Semax was originally developed in Russian research laboratories as a synthetic fragment of ACTH (adrenocorticotropic hormone), modified with a C-terminal addition for stability. It remains one of the most-referenced heptapeptides in that body of literature.
Do you provide a COA?
Yes, every Semax batch ships with a Certificate of Analysis confirming HPLC ≥99% purity.
⚠️ Research use only. All products referenced are supplied strictly as laboratory research chemicals / reference materials — not for human or veterinary use, not drugs, and not for diagnostic or therapeutic purposes. Nothing here is medical advice.
